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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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XCL2

Introduction

Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1.[1] It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1.[2] Its gene is located on chromosome 1 in humans.[3]

References

  1. ↑ Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). “Molecular cloning and functional characterization of human lymphotactin”. J Immunol. 155 (1): 203–9. PMID 7602097.
  2. ↑ Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). “Identification of single C motif-1/lymphotactin receptor XCR1”. J Biol Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.
  3. ↑ Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). “Structure and expression of two highly related genes encoding SCM-1/human lymphotactin”. FEBS Lett. 395 (1): 82–8. doi:10.1016/0014-5793(96)01004-6. PMID 8849694.