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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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XPA

Introduction

Xeroderma pigmentosum, complementation group A, also known as XPA, is a human gene.[1]

References

References

  1. ↑ “Entrez Gene: XPA xeroderma pigmentosum, complementation group A”.
Further reading

Further reading

  • Cleaver JE, Thompson LH, Richardson AS, States JC (1999). “A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy”. Hum. Mutat. 14 (1): 9–22. doi:10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6. PMID 10447254.
  • Morikawa K, Shirakawa M (2000). “Three-dimensional structural views of damaged-DNA recognition: T4 endonuclease V, E. coli Vsr protein, and human nucleotide excision repair factor XPA”. Mutat. Res. 460 (3–4): 257–75. PMID 10946233.
  • Satokata I, Tanaka K, Okada Y (1992). “Molecular basis of group A xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene”. Hum. Genet. 88 (6): 603–7. PMID 1339397.
  • Satokata I, Tanaka K, Yuba S, Okada Y (1992). “Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A xeroderma pigmentosum”. Mutat. Res. 273 (2): 203–12. PMID 1372103.
  • Miyamoto I, Miura N, Niwa H; et al. (1992). “Mutational analysis of the structure and function of the xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair”. J. Biol. Chem. 267 (17): 12182–7. PMID 1601884.
  • Satokata I, Tanaka K, Miura N; et al. (1991). “Characterization of a splicing mutation in group A xeroderma pigmentosum”. Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9908–12. PMID 1702221.
  • Miura N, Miyamoto I, Asahina H; et al. (1991). “Identification and characterization of xpac protein, the gene product of the human XPAC (xeroderma pigmentosum group A complementing) gene”. J. Biol. Chem. 266 (29): 19786–9. PMID 1918083.
  • Tanaka K, Miura N, Satokata I; et al. (1990). “Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain”. Nature. 348 (6296): 73–6. doi:10.1038/348073a0. PMID 2234061.
  • Li L, Lu X, Peterson CA, Legerski RJ (1995). “An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair”. Mol. Cell. Biol. 15 (10): 5396–402. PMID 7565690.
  • Nagai A, Saijo M, Kuraoka I; et al. (1995). “Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein”. Biochem. Biophys. Res. Commun. 211 (3): 960–6. PMID 7598728.
  • Farndon PA, Morris DJ, Hardy C; et al. (1995). “Analysis of 133 meioses places the genes for nevoid basal cell carcinoma (Gorlin) syndrome and Fanconi anemia group C in a 2.6-cM interval and contributes to the fine map of 9q22.3”. Genomics. 23 (2): 486–9. doi:10.1006/geno.1994.1528. PMID 7835901.
  • Park CH, Mu D, Reardon JT, Sancar A (1995). “The general transcription-repair factor TFIIH is recruited to the excision repair complex by the XPA protein independent of the TFIIE transcription factor”. J. Biol. Chem. 270 (9): 4896–902. PMID 7876263.
  • Li L, Elledge SJ, Peterson CA; et al. (1994). “Specific association between the human DNA repair proteins XPA and ERCC1”. Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5012–6. PMID 8197174.
  • Park CH, Sancar A (1994). “Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins”. Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5017–21. PMID 8197175.
  • Satokata I, Iwai K, Matsuda T; et al. (1994). “Genomic characterization of the human DNA excision repair-controlling gene XPAC”. Gene. 136 (1–2): 345–8. PMID 8294029.
  • Tanaka K (1993). “The Japan Society of Human Genetics Award Lecture. Molecular analysis of xeroderma pigmentosum group A gene”. Jpn. J. Hum. Genet. 38 (1): 1–14. PMID 8504220.
  • Topping RS, Myrand SP, Williams BL; et al. (1996). “Characterization of the human XPA promoter”. Gene. 166 (2): 341–2. PMID 8543191.
  • Lench NJ, Telford EA, Andersen SE; et al. (1997). “An EST and STS-based YAC contig map of human chromosome 9q22.3”. Genomics. 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
  • Selby CP, Sancar A (1997). “Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II”. J. Biol. Chem. 272 (3): 1885–90. PMID 8999876.
  • Hayashi T, Takao M, Tanaka K, Yasui A (1998). “ERCC1 mutations in UV-sensitive Chinese hamster ovary (CHO) cell lines”. Mutat. Res. 407 (3): 269–76. PMID 9653453.

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