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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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XPC (gene)

Introduction

Xeroderma pigmentosum, complementation group C, also known as XPC, is a human gene involved in the recognition of bulky DNA adducts in Nucleotide Excision Repair.[1]

References

References

  1. ↑ “Entrez Gene: XPC xeroderma pigmentosum, complementation group C”.
Further reading

Further reading

  • Cleaver JE, Thompson LH, Richardson AS, States JC (1999). “A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy”. Hum. Mutat. 14 (1): 9–22. doi:10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6. PMID 10447254.
  • El-Deiry WS (2003). “Transactivation of repair genes by BRCA1”. Cancer Biol. Ther. 1 (5): 490–1. PMID 12496474.
  • Sugasawa K (2007). “UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair”. J. Mol. Histol. 37 (5–7): 189–202. doi:10.1007/s10735-006-9044-7. PMID 16858626.
  • Legerski R, Peterson C (1993). “Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C.”. Nature. 360 (6404): 610. doi:10.1038/360610b0. PMID 1461286.
  • Legerski R, Peterson C (1992). “Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C.”. Nature. 359 (6390): 70–3. doi:10.1038/359070a0. PMID 1522891.
  • Legerski RJ, Liu P, Li L; et al. (1994). “Assignment of xeroderma pigmentosum group C (XPC) gene to chromosome 3p25”. Genomics. 21 (1): 266–9. doi:10.1006/geno.1994.1256. PMID 8088800.
  • Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. PMID 8125298.
  • Masutani C, Sugasawa K, Yanagisawa J; et al. (1994). “Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23”. EMBO J. 13 (8): 1831–43. PMID 8168482.
  • Li L, Bales ES, Peterson CA, Legerski RJ (1994). “Characterization of molecular defects in xeroderma pigmentosum group C.”. Nat. Genet. 5 (4): 413–7. doi:10.1038/ng1293-413. PMID 8298653.
  • Li L, Peterson C, Legerski R (1996). “Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene”. Nucleic Acids Res. 24 (6): 1026–8. PMID 8604333.
  • van der Spek PJ, Eker A, Rademakers S; et al. (1996). “XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes”. Nucleic Acids Res. 24 (13): 2551–9. PMID 8692695.
  • Li L, Lu X, Peterson C, Legerski R (1997). “XPC interacts with both HHR23B and HHR23A in vivo”. Mutat. Res. 383 (3): 197–203. PMID 9164480.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. PMID 9373149.
  • Zeng L, Quilliet X, Chevallier-Lagente O; et al. (1998). “Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C.”. Gene Ther. 4 (10): 1077–84. doi:10.1038/sj.gt.3300495. PMID 9415314.
  • Khan SG, Levy HL, Legerski R; et al. (1998). “Xeroderma pigmentosum group C splice mutation associated with autism and hypoglycinemia”. J. Invest. Dermatol. 111 (5): 791–6. doi:10.1046/j.1523-1747.1998.00391.x. PMID 9804340.
  • Yokoi M, Masutani C, Maekawa T; et al. (2000). “The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA”. J. Biol. Chem. 275 (13): 9870–5. PMID 10734143.
  • Batty D, Rapic’-Otrin V, Levine AS, Wood RD (2000). “Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites”. J. Mol. Biol. 300 (2): 275–90. doi:10.1006/jmbi.2000.3857. PMID 10873465.
  • Araújo SJ, Nigg EA, Wood RD (2001). “Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome”. Mol. Cell. Biol. 21 (7): 2281–91. doi:10.1128/MCB.21.7.2281-2291.2001. PMID 11259578.
  • Araki M, Masutani C, Takemura M; et al. (2001). “Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair”. J. Biol. Chem. 276 (22): 18665–72. doi:10.1074/jbc.M100855200. PMID 11279143.

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