Xylazine

Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other large mammals {non-human}. An analogue of clonidine, it is an agonist at the α₂ class of adrenergic receptor. As with other α₂ agonists, adverse effects include bradycardia, conduction disturbances, and myocardial depression. Yohimbine (Yobine) can be used to reverse xylazine effects. In veterinary anesthesia, xylazine is often used in combination with ketamine. No formal information in humans available. Xylazine is sold by Bayer under the brand name Rompun.

• McCurnin, DM, and JM Bassert. Clinical Textbook for Veterinary Technicians, 5th ed. Saunders, Philadelphia, PA. 2002.
• Bayer Healthcare – Rompun Homepage http://www.rompun.com/. 2005.
• Wright, Dr. Bob. Human Health Concerns When Working With Medications Around Horses. Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA). http://www.omafra.gov.on.ca/english/livestock/horses/facts/00-063.html. 2005.

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