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ZBTB1

Introduction

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.[1]

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.[2][3]

References

  1. ↑ “Entrez Gene: Zinc finger and BTB domain containing 1”.
  2. ↑ Siggs OM, Li X, Xia Y, Beutler B (January 2012). “ZBTB1 is a determinant of lymphoid development”. The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. PMC 3260866. PMID 22201126.
  3. ↑ Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (August 2012). “Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development”. Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355. PMID 22753936.