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ZFYVE16
Introduction
Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene.[1][2]
The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004).[supplied by OMIM][2]
In melanocytic cells ZFYVE16 gene expression may be regulated by MITF.[3]
References
References
- β Seet LF, Hong W (Nov 2001). “Endofin, an endosomal FYVE domain protein”. J Biol Chem. 276 (45): 42445β54. doi:10.1074/jbc.M105917200. PMIDΒ 11546807.
- β 2.0 2.1 “Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16”.
- β Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). “Novel MITF targets identified using a two-step DNA microarray strategy”. Pigment Cell Melanoma Res. 21 (6): 665β76. doi:10.1111/j.1755-148X.2008.00505.x. PMIDΒ 19067971.
- β Seet, Li-Fong; Liu Ningsheng; Hanson Brendon J; Hong Wanjin (Feb 2004). “Endofin recruits TOM1 to endosomes”. J. Biol. Chem. United States. 279 (6): 4670β9. doi:10.1074/jbc.M311228200. ISSNΒ 0021-9258. PMIDΒ 14613930.
Further reading
Further reading
- Nagase T, Ishikawa K, Nakajima D, et al. (1997). “Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro”. DNA Res. 4 (2): 141β50. doi:10.1093/dnares/4.2.141. PMIDΒ 9205841.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899β903. Bibcode:2002PNAS…9916899M. doi:10.1073/pnas.242603899. PMCΒ 139241. PMIDΒ 12477932.
- Seet LF, Liu N, Hanson BJ, Hong W (2004). “Endofin recruits TOM1 to endosomes”. J. Biol. Chem. 279 (6): 4670β9. doi:10.1074/jbc.M311228200. PMIDΒ 14613930.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40β5. doi:10.1038/ng1285. PMIDΒ 14702039.
- Brill LM, Salomon AR, Ficarro SB, et al. (2004). “Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry”. Anal. Chem. 76 (10): 2763β72. doi:10.1021/ac035352d. PMIDΒ 15144186.
- Colland F, Jacq X, Trouplin V, et al. (2004). “Functional Proteomics Mapping of a Human Signaling Pathway”. Genome Res. 14 (7): 1324β32. doi:10.1101/gr.2334104. PMCΒ 442148. PMIDΒ 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121β7. doi:10.1101/gr.2596504. PMCΒ 528928. PMIDΒ 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). “Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nat. Biotechnol. 23 (1): 94β101. doi:10.1038/nbt1046. PMIDΒ 15592455.
- Rual JF, Venkatesan K, Hao T, et al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173β8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMIDΒ 16189514.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). “Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55β65. doi:10.1101/gr.4039406. PMCΒ 1356129. PMIDΒ 16344560.
- Zhao BM, Hoffmann FM (2006). “Inhibition of Transforming Growth Factor-Ξ²1βinduced Signaling and Epithelial-to-Mesenchymal Transition by the Smad-binding Peptide Aptamer Trx-SARA”. Mol. Biol. Cell. 17 (9): 3819β31. doi:10.1091/mbc.E05-10-0990. PMCΒ 1556379. PMIDΒ 16775010.
- Chen YG, Wang Z, Ma J, et al. (2007). “Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling”. J. Biol. Chem. 282 (13): 9688β95. doi:10.1074/jbc.M611704200. PMIDΒ 17272273.
- Chen Y, Low TY, Choong LY, et al. (2007). “Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells”. Proteomics. 7 (14): 2384β97. doi:10.1002/pmic.200600968. PMIDΒ 17570516.