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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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ZNRD1

Introduction

DNA-directed RNA polymerase I subunit RPA12 is an enzyme that in humans is encoded by the ZNRD1 gene.[1][2][3]

Function

Function

This gene encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. Alternate splicing of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.[3]

References

References

  1. ↑ Lepourcelet M, Andrieux N, Giffon T, Pichon L, Hampe A, Galibert F, Mosser J (Nov 1996). “Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence”. Genomics. 37 (3): 316–26. doi:10.1006/geno.1996.0566. PMID 8938444.
  2. ↑ Fan W, Wang Z, Kyzysztof F, Prange C, Lennon G (Jan 2000). “A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region”. Genomics. 63 (1): 139–41. doi:10.1006/geno.1999.6040. PMID 10662553.
  3. ↑ 3.0 3.1 “Entrez Gene: ZNRD1 zinc ribbon domain containing 1”.
Further reading

Further reading

  • Maruyama K, Sugano S (Jan 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Coriton O, Lepourcelet M, Hampe A, Galibert F, Mosser J (Dec 2000). “Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes”. Mammalian Genome. 11 (12): 1127–31. doi:10.1007/s003350010213. PMID 11130983.
  • Shi Y, Zhang Y, Zhao Y, Hong L, Liu N, Jin X, Pan Y, Fan D (Apr 2004). “Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein”. Cancer Biology & Therapy. 3 (4): 377–81. doi:10.4161/cbt.3.4.724. PMID 14726695.
  • Hong L, Zhang Y, Liu N, Liu C, Zhi M, Pan Y, Lan M, Sun L, Fan D (Aug 2004). “Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene”. Biochemical and Biophysical Research Communications. 321 (3): 611–6. doi:10.1016/j.bbrc.2004.07.007. PMID 15358150.
  • Hong L, Han Y, Shi R, Shao X, Sun L, Zhang Y, Huang D, Chen Z, Zhang G, Liang J, Hu S, Fan D (Jan 2005). “ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase”. Cancer Biology & Therapy. 4 (1): 60–4. doi:10.4161/cbt.4.1.1375. PMID 15662122.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). “A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Hong L, Zhao Y, Han Y, Guo W, Jin H, Qiao T, Che Z, Fan D (Aug 2007). “Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells”. Carcinogenesis. 28 (8): 1622–8. doi:10.1093/carcin/bgm064. PMID 17389617.
  • Hong L, Wang J, Zhao Y, Han Z, Zhou X, Guo W, Zhang X, Jin H, Wu K, Ding J, Fan D (Dec 2007). “DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1”. Cancer Investigation. 25 (8): 699–705. doi:10.1080/07357900701566304. PMID 18058465.