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Zinc finger protein 426
Introduction
Zinc finger protein 426 is a protein that in humans is encoded by the ZNF426 gene. [1]
Function
Function
Kaposi’s sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene.
Further reading
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.