Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Zocor overdose
Introduction
Overdosage topics
Overdose in clinical trials
Overdose in patients
Dialyzability of Simvastatin
Overdose in clinical trials
Significant lethality was observed in mice after a single oral dose of 9 g/m2. No evidence of lethality
was observed in rats or dogs treated with doses of 30 and 100 g/m2, respectively. No specific diagnostic
signs were observed in rodents. At these doses the only signs seen in dogs were emesis and mucoid
stools. Return to top
Overdose in patients
A few cases of overdosage with ZOCOR have been reported; the maximum dose taken was 3.6 g. All
patients recovered without sequelae. Until further experience is obtained, no specific treatment of
overdosage with ZOCOR can be recommended. Return to top
Dialyzability of Simvastatin
The dialyzability of simvastatin and its metabolites in man is not known at present. Return to top
Adapted from the FDA Package Insert.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]