Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Myleofibrosis
Introduction
Overview
Overview
Myleofibrosis is a disorder of the bone marrow, in which the marrow is replaced by fibrous (scar) tissue (collagen).
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Historical Perspective
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Classification
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Pathophysiology
Overview
Pathophysiology
In primary myelofibrosis, a progressive scarring (fibrosis) of the bone marrow occurs. As a result, blood forms in sites other than the bone marrow, such as the liver and spleen. This causes an enlargement of these organs. The cause and risk factors are unknown. It commonly occurs in the spent phase of Polycythemia Rubra Vera, possibly in response to the medication hydroxyurea poisoning the marrow.
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Causes
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Differentiating Myleofibrosis from other Diseases
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Epidemiology and Demographics
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Risk Factors
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Screening
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Natural History, Complications and Prognosis
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Diagnosis
Diagnosis
History and Symptoms | Physical Examination |Laboratory Findings | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]