Anaplastic large cell lymphoma laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2], Kamal Akbar, M.D.[3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]

Laboratory tests for anaplastic large cell lymphoma include complete blood count (CBC), blood chemistry studies, flow cytometry, FISH, immunohistochemistry, and immunophenotyping.

Laboratory tests for anaplastic large cell lymphoma include:^[1][2]

• Complete blood count (CBC)

• Anemia
• Thrombocytopenia

• Blood chemistry studies

• Increased LDH

• Flow cytometry
• Fluorescence in situ hybridization (FISH)

• Negative for the Epstein-Barr virus (EBV)

• Immunohistochemistry

• Negative for human herpes virus-8 (HHV8)

• Immunophenotyping

• Strongly immunoreactive for CD30, Anaplastic lymphoma kinase (ALK), EMA, and vimentin
• Negative for AE1/AE3, CK20, CK7, CK5/6, P63, SMA, HMB-45, pan-Melan, S-100, Myo D1, synaptophysin, CD56, desmin, CD15, CD20, Pax-5, and CD3

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