Primary mediastinal large B-cell lymphoma physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2]

Patients with primary mediastinal large B-cell lymphoma usually appear normal. Physical examination of patients with primary mediastinal large B-cell lymphoma is usually remarkable for painless swellings, particularly [[swollen face]. Other physical findings include fever, lymphadenopaty.

Physical examination of patients with primary mediastinal large B-cell lymphoma is usually normal.

• Patients with primary mediastinal large B-cell lymphoma usually appear normal.

• Fever is often present

• Rash

• Cervical lymphadenopathy
• Facial edema

• Thoracic masses suggestive of central lymphadenopathy
• Localized anterosuperior mediastinal mass

• Abdominal masses suggestive of central lymphadenopathy

• Peripheral lymphadenopathy

Laboratory tests for primary mediastinal large B-cell lymphoma include:

• Complete blood count (CBC)
• Blood chemistry studies
• Liver function tests
• Serum LDH levels
• Beta 2 microglobulin levels
• Cytogenetic analysis
• Flow cytometry
• Immunohistochemistry
• Immunophenotyping
  • Positive: CD19, CD79a, CD20, CD30, and CD22