Renal amyloidosis physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Physical examination of patients with renal amyloidosis is usually remarkable for swelling, hepatosplenomegaly, facial or neck purpura and macroglossia. Fatigue and unintentional weight loss, are common in patients with AL amyloidosis. Tachycardia/bradycardia depends on the accompanying complication. Pulmonary fine crackles, faint pulmonary auscultation, suggestive of pleural effusion, decreased tactile fremitus and dull percussion.

Physical examination of patients with renal amyloidosis is usually remarkable for swelling, hepatosplenomegaly, facial or neck purpura and macroglossia. Fatigue and unintentional weight loss, are common in patients with AL amyloidosis. ^[1][2][3][4]

• Patient appears well in the earlier stages of the disease^[5]
• Patient appears ill in the late stages of the disease due to multi-organ involvement^[6]

• Fever depends on accompanying infection
• Tachycardia/bradycardia depends on the accompanying complication^[5]
• Tachypnea/bradypnea depends on the accompanying complication^[6]

• Pupura ^[7]

• Periorbital edema^[5]

• Pulmonary fine crackles
• Faint pulmonary auscultation, suggestive of pleural effusion
• Decreased tactile fremitus
• Dull percussion^[6]

• Abdominal distension
• Shifting dullness, suggestive of ascites
• Dull percussion

• Pitting edema in lower extremities bilaterally

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