Acute lymphoblastic leukemia diagnostic study of choice

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Shyam Patel [2]

Overview

The diagnostic study of choice for acute lymphoblastic lymphoma is bone marrow biopsy.

Diagnostic study of choice

The diagnostic study of choice for acute lymphoblastic lymphoma is bone marrow biopsy.^[1]^[2]
A bone marrow biopsy must show 20% or greater blasts of lymphoid immunophenotype^[3]
This diagnostic criteria is very similar to that of acute myeloid leukemia.^[4]

On bone marrow biopsy the following result is a confirmation of acute lymphoblastic leukemia:

The various investigations must be performed in the following order:

References

↑ Thomas X, Le QH, Danaïla C, Lhéritier V, Ffrench M (October 2002). “Bone marrow biopsy in adult acute lymphoblastic leukemia: morphological characteristics and contribution to the study of prognostic factors”. Leuk. Res. 26 (10): 909–18. PMID 12163052.
↑ Kröber SM, Greschniok A, Kaiserling E, Horny HP (April 2000). “Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens”. MP, Mol. Pathol. 53 (2): 83–7. PMC 1186910. PMID 10889907.
↑ Chiaretti S, Zini G, Bassan R (2014). “Diagnosis and subclassification of acute lymphoblastic leukemia”. Mediterr J Hematol Infect Dis. 6 (1): e2014073. doi:10.4084/MJHID.2014.073. PMC 4235437. PMID 25408859.
↑ Terwilliger T, Abdul-Hay M (2017). “Acute lymphoblastic leukemia: a comprehensive review and 2017 update”. Blood Cancer J. 7 (6): e577. doi:10.1038/bcj.2017.53. PMC 5520400. PMID 28665419.

Overview