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Adult T-cell leukemia differential diagnosis
Introduction
Overview
Overview
Adult T-cell leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
Differentiating Adult T-cell Leukemia from other Diseases
Differentiating Adult T-cell Leukemia from other Diseases
- Adult T-cell leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.[1][2][3][4]
- Based on the expression of cell surface markers, the table below differentiates adult T-cell leukemia from other diseases that cause similar clinical presentations:
| Differential Diagnosis | Surface Immunoglobulin | CD5 | CD22/FMC7 | CD23 | CD79b | CD103 |
|---|---|---|---|---|---|---|
|
Chronic lymphocytic leukemia |
Weakly positive |
Positive |
Negative |
Positive |
Negative |
Positive/Negative |
|
Prolymphocytic leukemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive |
Negative |
|
Hairy cell leukemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive/Negative |
Positive |
|
Mantle cell lymphoma |
Positive |
Positive |
Strongly positive |
Negative |
Strongly positive |
Negative |
|
Follicular lymphoma |
Strongly positive |
Negative |
Positive |
Negative |
Strongly positive |
Negative |
- Adult T-cell leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:
- Splenic marginal zone lymphoma
- Nodal marginal zone lymphoma
- Lymphoplasmacytic lymphoma
- Sézary syndrome
References
References
- ↑ Adult T-cell leukemia/lymphoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Adult_T-cell_leukemia/lymphoma Accessed on November, 3 2015
- ↑ Chuang SS, Ichinohasama R, Chu JS, Ohshima K (May 2010). “Differential diagnosis of angioimmunoblastic T-cell lymphoma with seropositivity for anti-HTLV antibody from adult T-cell leukemia/lymphoma”. Int. J. Hematol. 91 (4): 687–91. doi:10.1007/s12185-010-0540-x. PMID 20198459.
- ↑ Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011
- ↑ RodrÃguez-Zúñiga M, Cortez-Franco F, Qujiano-Gomero E (June 2018). “Adult T-Cell Leukemia/Lymphoma. Review of the Literature”. Actas Dermosifiliogr. 109 (5): 399–407. doi:10.1016/j.ad.2017.08.014. PMID 29685460. Vancouver style error: initials (help)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]