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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Anti-β2 glycoprotein I antibody

Introduction

Anti-β2 glycoprotein I antibody

Anti-β2 glycoprotein I antibody

Anti-β2 glycoprotein I antibodies along with anti-cardiolipin antibodies and lupus anticoagulant are involved in thrombosis and sclerosis in the antiphospholipid syndrome and autoimmune form of deep vein thrombosis. These antibodies interfere with factor X of coagulation cascade factors. The HLA-DR4-DQ3, DR4-DQ8, and HLA-DR7 are found to be involved in the pathogenesis of these antibodies.[1][2][3][4][5]

References

References

  1. ↑ Kouttab NM, Fowler AK, Strickland JE, Hellman A (November 1976). “Suprresion of in vitro lymphocyte stimulation in mice by uterine and placental extracts”. J. Immunol. 117 (5 Pt 1): 1644–50. PMID 137261.
  2. ↑ Galli M, Bevers EM, Comfurius P, Barbui T, Zwaal RF (March 1993). “Effect of antiphospholipid antibodies on procoagulant activity of activated platelets and platelet-derived microvesicles”. Br. J. Haematol. 83 (3): 466–72. PMID 8485053.
  3. ↑ Tsutsumi A, Matsuura E, Ichikawa K, Fujisaku A, Mukai M, Kobayashi S, Koike T (September 1996). “Antibodies to beta 2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus”. Arthritis Rheum. 39 (9): 1466–74. PMID 8814057.
  4. ↑ Shi W, Chong BH, Hogg PJ, Chesterman CN (August 1993). “Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of the factor Xa generating activity of platelets”. Thromb. Haemost. 70 (2): 342–5. PMID 8236146.
  5. ↑ Klitz W, Maiers M, Spellman S, Baxter-Lowe LA, Schmeckpeper B, Williams TM, Fernandez-Viña M (October 2003). “New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans”. Tissue Antigens. 62 (4): 296–307. PMID 12974796.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Mehrian Jafarizade, M.D [2]