Antiphospholipid syndrome epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Feham Tariq, MD [2]

Overview

The incidence of antiphospholipid syndrome (APS) is approximately 5 cases per 100,000 persons per year. The prevalence of APS is approximately 40-50 cases per 100,000 persons worldwide. APS due to systemic lupus erythematosus (SLE) is more commonly seen in the African American and Hispanic population. Middle aged women are more commonly affected by APS than males.

Epidemiology and Demographics

The epidemiology and demographics of antiphospholipid syndrome is as follows:^[1]^[2]^[3]^[4]

Incidence

The incidence of antiphospholipid syndrome (APS) is approximately 5 cases per 100,000 persons per year.

Prevalence

The prevalence of APS is approximately 40-50 cases per 100,000 persons worldwide.

Case-fatality rate/Mortality rate

The case-fatality rate/mortality rate of catastrophic APS is approximately 50%.

Age

The commonly affected age groups are young to middle aged adolescents.
However, APS is also seen in children and elderly age group.

Race

APS due to systemic lupus erythematosus (SLE) is more commonly seen in the African American and Hispanic population.

Gender

Middle aged women are more commonly affected by APS than males.

Region

There is no particular regional predilection.

References

↑ Cervera R (2017). “Antiphospholipid syndrome”. Thromb Res. 151 Suppl 1: S43–S47. doi:10.1016/S0049-3848(17)30066-X. PMID 28262233.
↑ Gómez-Puerta JA, Cervera R (2014). “Diagnosis and classification of the antiphospholipid syndrome”. J Autoimmun. 48-49: 20–5. doi:10.1016/j.jaut.2014.01.006. PMID 24461539.
↑ Lockshin MD (2008). “Update on antiphospholipid syndrome”. Bull NYU Hosp Jt Dis. 66 (3): 195–7. PMID 18937631.
↑ Gómez-Puerta, Jose A.; Cervera, Ricard (2014). “Diagnosis and classification of the antiphospholipid syndrome”. Journal of Autoimmunity. 48-49: 20–25. doi:10.1016/j.jaut.2014.01.006. ISSN 0896-8411.

[pmid28262233-1] Cervera R (2017). “Antiphospholipid syndrome”. Thromb Res. 151 Suppl 1: S43–S47. doi:10.1016/S0049-3848(17)30066-X. PMID 28262233.

[pmid24461539-2] Gómez-Puerta JA, Cervera R (2014). “Diagnosis and classification of the antiphospholipid syndrome”. J Autoimmun. 48-49: 20–5. doi:10.1016/j.jaut.2014.01.006. PMID 24461539.

[pmid18937631-3] Lockshin MD (2008). “Update on antiphospholipid syndrome”. Bull NYU Hosp Jt Dis. 66 (3): 195–7. PMID 18937631.

[Gómez-PuertaCervera2014-4] Gómez-Puerta, Jose A.; Cervera, Ricard (2014). “Diagnosis and classification of the antiphospholipid syndrome”. Journal of Autoimmunity. 48-49: 20–25. doi:10.1016/j.jaut.2014.01.006. ISSN 0896-8411.

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