Antistreptococcal antibodies
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Overview
Antistreptococcal antibodies are antibodies against a series of streptococcal exoantigens. They play a critical role in acute infections of the body surfaces, and certain organs.
Antistreptolysin O titre (AS(L)O titre or AS(L)OT) – titre of (serum) antistreptolysin O antibodies; a blood test used to assist in the diagnosis of a streptococcal infection or indicate a past exposure to streptococci. The ASOT helps direct the antimicrobial treatment and is used to assist in the diagnosis of scarlet fever, rheumatic fever and post infectious glomerulonephritis. The false negatives rate is 20-30%.[1] If a false negative is suspected then an anti-DNase B titre should be sought. False positives can result from liver disease and tuberculosis.[1]
Reference Range
Reference Range
| ASO/ASL | Up to 200 IU (adults) [1] but normal ranges vary from laboratory to laboratory and by age.[2] |
| Up to 150 IU (children) | |
| ADNase | Up to 200 IU |
Differential Diagnosis
Differential Diagnosis
In alphabetical order. [3] [4]
Increased Antistreptococcal Antibodies
- Acute poststreptococcal glomerulonephritis
- Chronic hepatitis
- Erysipelas
- Hyperlipidemia with obesity
- Lipid nephrosis
- Membranoproliferative glomerulonephritis
- Polyarteritis Nodosa
- Rheumatic Carditis
- Rheumatic Fever
- Scarlet Fever
- Streptococcal angina
- Streptococcal Infection
- Tuberculosis
Decreased Antistreptococcal Antibodies
- Antibody Deficiency Syndrome
- Exudative enteropathy
- Nephrotic Syndrome
- Newborns
References
References
- ↑ 1.0 1.1 1.2 Antistreptococcal antibody titres. gpnotebook. URL: http://www.gpnotebook.co.uk/cache/-1630535637.htm. Accessed on: March 31, 2007.
- ↑ Danchin M, Carlin J, Devenish W, Nolan T, Carapetis J (2005). “New normal ranges of antistreptolysin O and antideoxyribonuclease B titres for Australian children”. J Paediatr Child Health. 41 (11): 583–6. PMID 16398843.
- ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
- ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
Suggested Links and Web Resources
Suggested Links and Web Resources
- Antistreptococcal antibody titres
- Antistreptolysin O Titer
- Antistreptolysin O Titer, Serum
- Streptococcal antibody tests
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