Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Aortic stenosis prevention
Introduction
Overview
Overview
The risk of developing aortic stenosis following rheumatic heart disease can be minimized with early antibiotic therapy among patients with documented streptococcal pharyngitis (strep throat).[1] Bicuspid aortic valve disease is a congenital variant and cannot be prevented. As for calcific aortic stenosis, a number of small, observational studies have demonstrated an association between lowering cholesterol levels and decreasing the progression of the aortic stenosis;[2] however, randomized clinical trials have failed to corroborate these findings.[3][4][5]
References
References
- ↑ Dajani A, Taubert K, Ferrieri P, Peter G, Shulman S (1995). “Treatment of acute streptococcal pharyngitis and prevention of rheumatic fever: a statement for health professionals. Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, the American Heart Association”. Pediatrics. 96 (4 Pt 1): 758–64. PMID 7567345.
- ↑ Moura LM, Ramos SF, Zamorano JL; et al. (2007). “Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis”. J. Am. Coll. Cardiol. 49 (5): 554–61. doi:10.1016/j.jacc.2006.07.072. PMID 17276178.
- ↑ Rossebø AB, Pedersen TR, Boman K, Brudi P, Chambers JB, Egstrup K; et al. (2008). “Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis”. N Engl J Med. 359 (13): 1343–56. doi:10.1056/NEJMoa0804602. PMID 18765433.
- ↑ Cowell SJ, Newby DE, Prescott RJ, Bloomfield P, Reid J, Northridge DB; et al. (2005). “A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis”. N Engl J Med. 352 (23): 2389–97. doi:10.1056/NEJMoa043876. PMID 15944423.
- ↑ Chan KL, Teo K, Dumesnil JG, Ni A, Tam J, ASTRONOMER Investigators (2010). “Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial”. Circulation. 121 (2): 306–14. doi:10.1161/CIRCULATIONAHA.109.900027. PMID 20048204.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Mohammed A. Sbeih, M.D. [2]; Usama Talib, BSc, MD [3]