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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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B-cell prolymphocytic leukemia causes

Introduction

Overview

Overview

Some mutations and genetic factors are thought to play a role in the pathogenesis of B-cell prolymphocytic leukemia. Some known mutations are: p53 gene mutation, 11q23 and 13q14 deletions and deletions from chromosome 11 and chromosome 13.

Genetics

References

References

  1. ↑ 1.0 1.1 Lens D, De Schouwer PJ, Hamoudi RA, Abdul-Rauf M, Farahat N, Matutes E, Crook T, Dyer MJ, Catovsky D (March 1997). “p53 abnormalities in B-cell prolymphocytic leukemia”. Blood. 89 (6): 2015–23. PMID 9058723.
  2. ↑ Brito-Babapulle V, Ellis J, Matutes E, Oscier D, Khokhar T, MacLennan K, Catovsky D (September 1992). “Translocation t(11;14)(q13;q32) in chronic lymphoid disorders”. Genes Chromosomes Cancer. 5 (2): 158–65. PMID 1381952.
  3. ↑ Solé F, Woessner S, Espinet B, Lloveras E, Florensa L, Pérez-Losada A, Vilà RM, Besses C, Sans-Sabrafen J (May 1998). “Cytogenetic abnormalities in three patients with B-cell prolymphocytic leukemia”. Cancer Genet. Cytogenet. 103 (1): 43–5. PMID 9595043.
  4. ↑ Lens D, Coignet LJ, Brito-Babapulle V, Lima CS, Matutes E, Dyer MJ, Catovsky D (June 1999). “B cell prolymphocytic leukaemia (B-PLL) with complex karyotype and concurrent abnormalities of the p53 and c-MYC gene”. Leukemia. 13 (6): 873–6. PMID 10360375.
  5. ↑ Ruchlemer R, Parry-Jones N, Brito-Babapulle V, Attolico I, Wotherspoon AC, Matutes E, Catovsky D (May 2004). “B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia”. Br. J. Haematol. 125 (3): 330–6. doi:10.1111/j.1365-2141.2004.04913.x. PMID 15086413.
  6. ↑ van der Velden VH, Hoogeveen PG, de Ridder D, Schindler-van der Struijk M, van Zelm MC, Sanders M, Karsch D, Beverloo HB, Lam K, Orfao A, Lugtenburg PJ, Böttcher S, van Dongen JJ, Langerak AW, Kappers-Klunne M, van Lom K (July 2014). “B-cell prolymphocytic leukemia: a specific subgroup of mantle cell lymphoma”. Blood. 124 (3): 412–9. doi:10.1182/blood-2013-10-533869. PMID 24891323.
  7. ↑ Miao Y, Wang R, Fan L, Qiu H, Wu Y, Chen Y, Xu W, Li J (2015). “Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia”. Int J Clin Exp Pathol. 8 (6): 7494–8. PMC 4525993. PMID 26261659.
  8. ↑ Lens D, Matutes E, Catovsky D, Coignet LJ (2000). “Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL)”. Leukemia. 14 (3): 427–30. PMID 10720137.


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2],Carlos A Lopez, M.D. [3]