The cardiac tamponade is most often attributed to the rupture of an acute myocardial infarction or an intrapericardial rupture of a dissecting ascending aortic aneurysm. In developed countries malignancy is the leading cause of cardiac tamponade secondary to pericardial effusion.The incidence of cardiac tamponade based on a giant sample size of about 216 million emergency admissions was about 115,638(0.05%). The incidence of cardiac tamponade increases with age; the mean age was around 61.9. Cardiac temponade mortality rate is significantly different due to its underlying cause.

• The incidence of cardiac tamponade based on a giant sample size of about 216 million emergency admissions was about 115,638(0.05%)^{_JACC:_Journal_of_the_American_College_of_Cardiology-1|[1][2][3][4]}

• Cardiac temponade mortality rate is significantly different due to its underlying cause.^{[5]_JACC:_Journal_of_the_American_College_of_Cardiology-1|[1][6]}
• Overall, hospitalized mortality rate is around 14.3% and sub groups with higher mortality are :
  1. Sepsis (odds ratio:3.17)
  2. Chest trauma (odds ratio:2.15)
  3. Metastatic cancer:(odds ratio:1.90)
  4. Acute kidney injury(odds ratio:1.91)
  5. Idiopathic pericarditis (odds ratio: 0.21, least cause of mortality)

• The incidence of cardiac tamponade increases with age; the mean age was around 61.9.^{_JACC:_Journal_of_the_American_College_of_Cardiology-1|[1][7]}

• There is no racial predilection to cardiac tamponade.

• Cardiac tamponade affects men and women equally.
• There is no study suggesting a meaningful sex difference among diagnosed patients.

• It needs around 12 days of hospitalization and a mean cost of $160,397.

• The leading cause of developing tamponade in developed countries is cancer.^[7]