Cholangiocarcinoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2] [3], Suveenkrishna Pothuru, M.B,B.S. [4]

Overview

Cholangiocarcinoma may be classified according to location of the tumor into three subtypes of Intrahepatic bile duct cancer, perihilar bile duct cancer, and extrahepatic bile duct cancer.

Classification

Cholangiocarcinoma may be classified according to location of the tumor into three subtypes:^[1]^[2]^[3]
- Intrahepatic bile duct cancer
- Perihilar bile duct cancer
- Extrahepatic bile duct cancer

Cellular Classification of Cholangiocarcinoma

Intrahepatic Bile Duct Cancer

Mass-forming tumor growth pattern
Periductal-infiltrating tumor growth pattern
Mixed mass-forming and periductal-infiltrating growth pattern

Perihilar Bile Duct Cancer

Carcinoma in situ
Adenocarcinoma

Intestinal type
Mucinous type
Clear cell type

Signet-ring cell carcinoma
Adenosquamous carcinoma
Squamous cell carcinoma
Small cell (oat cell) carcinoma
Undifferentiated carcinoma

Papillomatosis
Papillary carcinoma

Carcinoma, NOS

Extrahepatic Bile Duct Cancer

Carcinoma in situ
Adenocarcinoma, not otherwise specified (NOS)
Adenocarcinoma

Intestinal type
Mucinous type
Clear cell type

Signet-ring cell carcinoma
Adenosquamous carcinoma
Squamous cell carcinoma
Small cell (oat cell) carcinoma
Undifferentiated carcinoma

Papillomatosis
Papillary carcinoma

Noninvasive

Papillary carcinoma
- Invasive

Bismuth-Corlette classification

Type I: Tumors are distal to the hepatic duct confluence
Type II: Neoplasms extend to and involve the hepatic duct confluence
Type IIIA: Tumors involve the hepatic duct confluence and either the proximal right hepatic duct
Type IIIB: Tumors involve the hepatic duct confluence and either the proximal left hepatic duct
Type IV: Tumors extend into the bilateral proximal hepatic ducts up to the segmental bile ducts

References

↑ DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD (2007). “Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution”. Ann. Surg. 245 (5): 755–62. doi:10.1097/01.sla.0000251366.62632.d3. PMC 1877058. PMID 17457168.
↑ Aishima S, Oda Y (2015). “Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type”. J Hepatobiliary Pancreat Sci. 22 (2): 94–100. doi:10.1002/jhbp.154. PMID 25181580.
↑ Oliveira IS, Kilcoyne A, Everett JM, Mino-Kenudson M, Harisinghani MG, Ganesan K (2017). “Cholangiocarcinoma: classification, diagnosis, staging, imaging features, and management”. Abdom Radiol (NY). 42 (6): 1637–1649. doi:10.1007/s00261-017-1094-7. PMID 28271275.

[pmid17457168-1] DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD (2007). “Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution”. Ann. Surg. 245 (5): 755–62. doi:10.1097/01.sla.0000251366.62632.d3. PMC 1877058. PMID 17457168.

[pmid25181580-2] Aishima S, Oda Y (2015). “Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type”. J Hepatobiliary Pancreat Sci. 22 (2): 94–100. doi:10.1002/jhbp.154. PMID 25181580.

[pmid28271275-3] Oliveira IS, Kilcoyne A, Everett JM, Mino-Kenudson M, Harisinghani MG, Ganesan K (2017). “Cholangiocarcinoma: classification, diagnosis, staging, imaging features, and management”. Abdom Radiol (NY). 42 (6): 1637–1649. doi:10.1007/s00261-017-1094-7. PMID 28271275.

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Cholangiocarcinoma classification

Overview

Classification

Cellular Classification of Cholangiocarcinoma

References

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