Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Chronic lymphocytic leukemia laboratory tests
Introduction
Overview
Overview
Laboratory findings consistent with the diagnosis of chronic lymphocytic leukemia include abnormal complete blood count, immunohistochemistry, and electrophoresis. Monoclonality of kappa and lambda producing B cells is a key diagnostic feature among patients with chronic lymphocytic leukemia.[1][2]
Laboratory Findings
Laboratory Findings
Complete Blood Count
- Absolute lymphocytosis (>5000 cells/μl)[1][2]
- Decreased hemoglobin concentration
- Decreased platelets count
Blood Smear
Metabolic Panel
- Elevated low-density lipoprotein level[1][2]
Quantitative Immunoglobulin Assay
- Quantitative measurement of IgA, IgG, and IgM immunoglobulins to detect hypogammaglobulinemia[1][2]
- Elevated β2-microglobulin level
Electrophoresis
- Monoclonality of kappa and lambda producing B cells is a key diagnostic feature among patients with chronic lymphocytic leukemia.[1][2]
Immunohistochemistry
References
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Nabhan C, Rosen ST (2014). “Chronic lymphocytic leukemia: a clinical review”. JAMA. 312 (21): 2265–76. doi:10.1001/jama.2014.14553. PMID 25461996.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]