Cryptogenic organizing pneumonia laboratory findings

There are no specific laboratory findings associated with cryptogenic organizing pneumonia. If there are symptoms of fever, cough and dyspnea, then tests like CBC, creatinine, urinalysis, ESR, CRP. Further tests are done to rule out the etiology of the cryptogenic organizing pneumonia.

• There are no specific laboratory findings associated with cryptogenic organizing pneumonia.
• If there is the history of cryptogenic organizing pneumonia and patients present with a cough, fever, and dyspnea then following laboratory test has to be done:^[1]
  • Complete blood count with differentials- leukocytosis is found in most of the patients.^[2]
  • Blood urea nitrogen
  • Creatinine
  • Urinalysis
  • ESR
  • C-reactive protein
• To find the etiology of cryptogenic organizing pneumonia following tests are done:
  • Test for antibodies to rule out connective tissue disorder.
    • Antinuclear antibody
    • Rheumatoid factor
    • Anti-topoisomerase [anti-Scl70] antibodies
    • Anti-centromere antibodies
    • Anti-double-stranded DNA antibodies
    • Anti-J01 antibodies
  • To rule out pneumonia, following tests are done:^[3]
    • Blood cultures
    • Sputum gram stain
    • Sputum enzyme immunoassay (EIA)
    • Immunofluorescence
    • Polymerase chain reaction (PCR) for respiratory viruses
    • Urinary studies for pneumococcal and Legionella antigen
    • HIV testing