Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Donovanosis historical perspective
Introduction
Overview
Overview
Donovanosis was first called “serpiginous ulcer” in 1882. Charles Donovan first identified the cause of these genital lesions in 1905, which he called “Donovan bodies,” since the etiologic agent was unknown. Aragão & Vianna classified the agent as Calymmatobacterium granulomatis in 1913. However, sequencing analysis by Carter et al. revealed that the agent should be reclassified to Klebsiella granulomatis.
Historical Perspective
Historical Perspective
- Donovanosis was first called “serpiginous ulcer“, dating back to 1882.[1]
- In 1905, Charles Donovan discovered intracellular bodies as the cause of this ulcer; the nature of the bodies was unknown and they were referred to as “Donovan bodies.”[2]
- Calymmatobacterium granulomatis was presumed to be the causative agent of donovanosis by Aragão & Vianna in 1913.
- However, gene sequencing of bacteria in Donovan bodies by Carter et al. revealed that the caustive agent should be reclassified to Klebsiella granulomatis.[3]
References
References
- ↑ McLeod K. (1882). “Precis of operations performed in the wards of the first surgeon, Medical College Hospital, during the year 1881”. Ind Med Gaz. 11: 113.
- ↑ Donovan, C. (1905). “Ulcerating Granuloma of the Pudenda”. Ind Med Gaz. 40: 414.
- ↑ Carter JS, Bowden FJ, Bastian I, Myers GM, Sriprakash KS, Kemp DJ (1999). “Phylogenetic evidence for reclassification of Calymmatobacterium granulomatis as Klebsiella granulomatis comb. nov”. Int J Syst Bacteriol. 49 Pt 4: 1695–700. doi:10.1099/00207713-49-4-1695. PMID 10555350.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nate Michalak, B.A.