
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions β written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Dysfunctional uterine bleeding future or investigational therapies
Introduction
Overview
Overview
Abnormal uterine bleeding has been found to affect a multitude of women, ranging from menarche to menopause. It can often result in conditions that affect an individual’s daily routine and personal life, such as anemia and infertility. Because of such complications, it is important to continue researching and studying the causes of abnormal bleeding and providing further knowledge.[1] Due to the prevalence and high cost associated with surgical treatment of underlying causes, treatment must be tailored to the individual woman. Biomarkers continue to be studied and may provide crucial information.[2] Future studied regarding progesterone antagonists and progesterone receptor modulators are also being studied and may prove helpful in future therapy.[3]
Future or Investigational Therapies
Future or Investigational Therapies
Biomarkers
A biomarker[2] is an indicator that may be measured and used as an indicator for treatment response. Biomarkers have been studied for underlying conditions leading to abnormal bleeding.
| Cause of Abnormal Bleeding | Associated Biomarkers |
|---|---|
| Polyps |
|
| Adenomyosis |
|
| Leiomyoma/ Fibroids |
|
| Coagulopathy[4] | |
| Ovulatory disorders |
|
| Endometrial disorders |
|
Elastography
Elastography, a type of medical imaging done using MRI and ultrasonography, is used as a noninvasive biomarker for fibroids and adenomyosis. This method of diagnosis shows promise in allowing for individualized care and treatment response.[5]
References
References
- β Levy-Zauberman Y, Pourcelot AG, Capmas P, Fernandez H (2017). “Update on the management of abnormal uterine bleeding”. J Gynecol Obstet Hum Reprod. 46 (8): 613β622. doi:10.1016/j.jogoh.2017.07.005. PMIDΒ 28716637.
- β 2.0 2.1 Chodankar R, Critchley HOD (2019). “Biomarkers in abnormal uterine bleedingβ ”. Biol Reprod. 101 (6): 1155β1166. doi:10.1093/biolre/ioy231. PMCΒ 6931000 Check
|pmc=value (help). PMIDΒ 30388215. - β Samuel NC, Clark TJ (2007). “Future research into abnormal uterine bleeding”. Best Pract Res Clin Obstet Gynaecol. 21 (6): 1023β40. doi:10.1016/j.bpobgyn.2007.03.018. PMIDΒ 17584533.
- β Munro MG, Critchley HOD, Fraser IS, FIGO Menstrual Disorders Committee (2019). “Corrigendum to “The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions” [Int J Gynecol Obstet 143(2018) 393-408.]”. Int J Gynaecol Obstet. 144 (2): 237. doi:10.1002/ijgo.12709. PMIDΒ 30609040.
- β Jondal DE, Wang J, Chen J, Gorny KR, Felmlee J, Hesly G; et al. (2018). “Uterine fibroids: correlations between MRI appearance and stiffness via magnetic resonance elastography”. Abdom Radiol (NY). 43 (6): 1456β1463. doi:10.1007/s00261-017-1314-1. PMCΒ 6731767 Check
|pmc=value (help). PMIDΒ 28952003.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Arooj Naz, M.B.B.S
