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Epoxyeicosatrienoic acid

Introduction

Chemical structure of 14,15-epoxyeicosatrienoic acid.

The Epoxyeicosatrienoic acids or EETs are signaling molecules formed by the action of Cytochrome P450 epoxygenase on 20-carbon essential fatty acids, such as arachidonic acid. These nonclassic eicosanoids act as short-range hormones, (i.e. they are autocrine and paracrine mediators) of the cardiovascular system and kidney. They produce vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.[1]

Biological effects

Biological effects

EETs are cardioprotective after ischemic heart attack and reperfusion.[2] They act in the corpus cavernosum to maintain penile erection.[3] Specific epoxidation of EET sites produces endogenous PPARα agonists.[4]

References

References

  1. ^ Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ. “Epoxyeicosatrienoic acids (EETs) in cardioprotection: Ischemic versus reperfusion injury”. Am J Physiol Heart Circ Physiol. date=2006 Feb 10. Retrieved 2006-03-11.
  2. ^ Jin L, Foss CE, Zhao X, Mills TM, Wang MH, McCluskey LP, Yaddanapud GS, Falck JR, Imig JD, Webb RC. (2006 Jan 13.). “Cytochrome P450 epoxygenases provide a novel mechanism for penile erection”. FASEB J. 2006 Mar;20(3):539-41. Retrieved 2006-03-11. Check date values in: |date= (help)PubMed cite.
  3. ^ Spector AA,Fang X, Snyder GD, Weintraub NL (2004). “Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function”. Prog Lipid Res. 43 (1): 55–90. PMID 14636671. Unknown parameter |month= ignored (help)
  4. ^ Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL (2007). “Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha”. Drug Metab Dispos. 37 (7): 1126–1134. PMID 17431031. Unknown parameter |month= ignored (help)

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