Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Erdheim-Chester disease
Introduction
Synonyms and keywords: Erdheim-Chester syndrome; polyostotic sclerosing histiocytosis; ECD
Overview
Overview
Erdheim-Chester disease is a rare form of non-Langerhans-cell histiocytosis. Usually, onset is in middle age. The disease involves an infiltration of lipid-laden macrophages, multinucleated giant cells, an inflammatory infiltrate of lymphocytes and histiocytes in the bone marrow, and a generalized sclerosis of the long bones.[1]
References
- ↑ “Erdheim-Chester disease at the Disease Database”. Retrieved 2007-03-25.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Historical Perspective
Overview
Historical Perspective
The first case of ECD was reported by W. Chester and Jakob Erdheim in 1930.[1]
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
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References
Causes
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References
Differentiating Erdheim-Chester disease from other Diseases
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References
Epidemiology and Demographics
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Overview
Epidemiology and Demographics
Age
ECD affects predominantly adults, with a mean age of 53 years.[1]
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Natural History, Complications and Prognosis
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References
Diagnosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Treatment
Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
Case Studies
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]