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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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FMNL2

Introduction

Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene.[1][2]

Expression

Expression

Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[1] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[3]) is regulated through autoinhibition, and may become activated through Rho proteins.[4] The FMNL2 gene is expressed in multiple human tissues.[5]

Function

Function

Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.[1]

Clinical significance

Clinical significance

FMNL2 expression is considerably higher in colorectal cancer tumors compared to normal tissue.[6]

See also

See also

References

References

  1. ↑ 1.0 1.1 1.2 “Entrez Gene: FMNL2 formin-like 2”.
  2. ↑ Katoh M, Katoh M (May 2003). “Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico”. Int. J. Oncol. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
  3. ↑ “formin-like protein 2 [Homo sapiens]” (NCBI Reference Sequence: NP_443137.2). National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R (April 2010). “Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC”. Oncogene. 29 (16): 2441–8. doi:10.1038/onc.2009.515. PMID 20101212.
  5. ↑ Gardberg M, Talvinen K, Kaipio K, Iljin K, Kampf C, Uhlen M, Carpén O (2010). “Characterization of Diaphanous-related formin FMNL2 in human tissues”. BMC Cell Biol. 11: 55. doi:10.1186/1471-2121-11-55. PMC 2912821. PMID 20633255.
  6. ↑ Zhu XL, Liang L, Ding YQ (November 2008). “Overexpression of FMNL2 is closely related to metastasis of colorectal cancer”. Int J Colorectal Dis. 23 (11): 1041–7. doi:10.1007/s00384-008-0520-2. PMID 18665374.