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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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FMNL3

Introduction

Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene.[1][2]

Function

Function

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.[1] The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif.[3] FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.[4]

See also

See also

References

References

  1. ↑ 1.0 1.1 “Entrez Gene: formin-like 3”.
  2. ↑ Katoh M, Katoh M (May 2003). “Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico”. International Journal of Oncology. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
  3. ↑ Heimsath EG, Higgs HN (Jan 2012). “The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends”. The Journal of Biological Chemistry. 287 (5): 3087–98. doi:10.1074/jbc.M111.312207. PMC 3270965. PMID 22094460.
  4. ↑ Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ (Jan 2013). “FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation”. Nature Structural & Molecular Biology. 20 (1): 111–8. doi:10.1038/nsmb.2462. PMC 3876896. PMID 23222643.
Further reading

Further reading