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GMP reductase
Introduction
GMP reductase EC 1.7.1.7 (Guanosine 5′-monophosphate oxidoreductase ) is an enzyme that catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP.[1]
NADPH + guanosine 5-phosphate = NADP+ + inosine 5-phosphate + NH3
It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides.
In melanocytic cells, GMP reductase gene expression may be regulated by MITF.[2]
References
References
- ↑ Andrews SC, Guest JR (Oct 1988). “Nucleotide sequence of the gene encoding the GMP reductase of Escherichia coli K12”. The Biochemical Journal. 255 (1): 35–43. doi:10.1042/bj2550035. PMC 1135187. PMID 2904262.
- ↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). “Novel MITF targets identified using a two-step DNA microarray strategy”. Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
External links
External links
- GMP+reductase at the US National Library of Medicine Medical Subject Headings (MeSH)