Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Hepatocellular adenoma historical perspective
Introduction
Overview
Overview
Hepatocellular adenoma was first described in 1958 by Edmondson as an encapsulated liver tumor that does not contain bile ducts. Baum reported the important relationship between oral contraceptive use and hepatocellular adenoma development in 1973. Edmondson, in 1976, published a case control study giving further evidence of this association.
Historical Perspective
Historical Perspective
- In 1958, hepatocellular adenoma was first described by Edmondson as an encapsulated liver tumor that does not contain bile ducts, when he identified two such lesions in 50,000 autopsies.[1][2]
- In 1973, Baum reported the important relationship between oral contraceptive use and development of hepatocellular adenomas in seven patients.[3][4]
- In the 1970s, several subsequent case series supported the hypothesis of an association between oral contraceptive pills and hepatocellular adenoma.[5]
- In 1976, Edmondson published a case control study giving further evidence of this association. [6]
References
References
- ↑ Barthelmes L, Tait IS (2005). “Liver cell adenoma and liver cell adenomatosis”. HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
- ↑ Barthelmes L, Tait IS (2005). “Liver cell adenoma and liver cell adenomatosis”. HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
- ↑ G. Klatskin (1977). “Hepatic tumors: possible relationship to use of oral contraceptives”. Gastroenterology. 73 (2): 386–394. PMID 194813. Unknown parameter
|month=ignored (help) - ↑ J. K. Baum, J. J. Bookstein, F. Holtz & E. W. Klein (1973). “Possible association between benign hepatomas and oral contraceptives”. Lancet (London, England). 2 (7835): 926–929. PMID 4126557. Unknown parameter
|month=ignored (help) - ↑ E. Horvath, K. Kovacs & R. C. Ross (1974). “Letter: Benign hepatoma in a young woman on contraceptive steroids”. Lancet (London, England). 1 (7853): 357–358. PMID 4131203. Unknown parameter
|month=ignored (help) - ↑ H. A. Edmondson, B. Henderson & B. Benton (1976). “Liver-cell adenomas associated with use of oral contraceptives”. The New England journal of medicine. 294 (9): 470–472. doi:10.1056/NEJM197602262940904. PMID 173996. Unknown parameter
|month=ignored (help)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]