Reticulum cell sarcoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

A malignant tumor of reticular tissue in the bone that is composed primarily of neoplastic histocytes.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

The dominant cell type is thought to be derived from histiocytes or macrophages. More recent thinking indicates that this cancer may arise from lymphocytes or immunoblasts.

• Large, foam filled histiocytes with numerous mitoses and scant stroma are present
• Stains for reticulum are positive
• Periodic Acid Schiff (PAS) stains are negative

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Reticulum cell sarcoma should be distinguished from the following diseases:

• Ewing’s sarcoma
• Fibrosarcoma
• Malignant Fibrous Histiocytoma
• Metastatic carcinoma
• Osteomyelitis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

• Presents in middle age

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