Common risk factors in the development of hypopituitarism may include pituitary tumor or space occupying lesion, pituitary apoplexy, severe blood loss such as Sheehan’s syndrome, pituitary surgery, cranial radiation, genetic defects, hypothalamic disease, immunosuppression, inflammatory processes, pituitary infarction, and non-compliance with hormone replacement therapy. Less common risk factors, include infiltrative disorders, traumatic brain injury causing skull fractures, ischemic stroke and subarachnoid hemorrhage.

Common risk factors of hypopituitarism include the following: ^{[1][2][3][4][3][5][6][7][8]}

• Pituitary tumor or space occupying lesion
• Pituitary apoplexy
• Severe loss of blood, such as Sheehan syndrome or postpartum hypopituitarism
• Pituitary surgery, such as hypophysectomy
• Cranial radiation
• Genetic defects
• Hypothalamic disease
• Immunosuppression, such as HIV and high dose glucocorticoid intake
• Inflammatory processes such as hypophysitis
• Pituitary infarction
• Non-compliance with hormone replacement therapy

Less common risk factors include:

• Infiltrative disorders such as sarcoidosis and histiocytosis^[9]
• Traumatic brain injury causing skull fractures^{[10][11][12][13][14]}
• Ischemic stroke^[15]
• Subarachnoid hemorrhage^{[11][16][17][18]}

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