Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
In utero DES exposure
Introduction
- A T-shaped configuration of the endometrial cavity is the most commonly associated abnormality from in utero diethylstilbestrol (DES) exposure, seen in 31% of exposed women.
- DES is a synthetic estrogen that was introduced in 1948
- DES was prescribed for women experiencing recurrent spontaneous abortions, premature deliveries, and other pregnancy complications. By increasing the synthesis of placental steroidal hormones, DES was thought to decrease the frequency of pregnancy loss.
- In utero exposure to DES was shown to be associated with clear cell carcinoma of the vagina, and use of the drug was abruptly discontinued in 1971 (incidence 0.14–1.4 per 1000 women exposed).
Diagnosis
Diagnosis
HSG
- Narrowed irregular endocervical canal.
- The opacified endometrial cavity appears small, with a shortened upper uterine segment, resulting in the characteristic T configuration
See Also
See Also
References for T-shaped uterus
References for T-shaped uterus
- Robert N. Troiano, and Shirley M. McCarthy. Müllerian Duct Anomalies: Imaging and Clinical Issues. Radiology 2004 233: 19-34.
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