Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Incidentaloma risk factors
Introduction
Overview
Overview
Most adrenocortical carcinomas are sporadic, but some occur as a component of hereditary cancer syndromes such as Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, and Multiple endocrine neoplasia type 1(MEN1).
Risk Factors
Risk Factors
Most adrenocortical carcinomas are sporadic, but some occur as a component of hereditary cancer syndromes.[1][2]
- Hereditary cancer syndromes:Â
- Li-Fraumeni syndrome (associated with inactivating mutations of the TP53 tumor suppressor gene on chromosome 17p):
- Breast cancer
- Soft tissue and bone sarcoma
- Brain tumors
- Beckwith-Wiedemann syndrome (associated with abnormalities in 11p15):
- Multiple endocrine neoplasia type 1 (MEN1) (associated with inactivating mutations of the MEN1 gene on chromosome 11q):
- Li-Fraumeni syndrome (associated with inactivating mutations of the TP53 tumor suppressor gene on chromosome 17p):
References
References
- ↑ Sidhu S, Sywak M, Robinson B, Delbridge L (2004). “Adrenocortical cancer: recent clinical and molecular advances”. Curr Opin Oncol. 16 (1): 13–8. PMID 14685087.
- ↑ Lynch HT, Radford B, Lynch JF (1990). “SBLA syndrome revisited”. Oncology. 47 (1): 75–9. PMID 2300390.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]