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Iodine deficiency

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Iodine is an essential trace element; the thyroid hormones thyroxine and triiodotyronine contain iodine. In areas where there is little iodine in the diet—typically remote inland areas where no marine foods are eaten—iodine deficiency gives rise to goiter (so-called endemic goitre), as well as cretinism, which results in developmental delays and other health problems

In some such areas, this is now combatted by the addition of small amounts of iodine to table salt in form of sodium iodide, potassium iodide, potassium iodate—this product is known as iodized salt. Iodine compounds have also been added to other foodstuffs, such as flour, in areas of deficiency.

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Iodine Deficiency from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

References

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Historical Perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Historical Perspective

References

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Classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Classification

References

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Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Iodine is an essential trace element; the thyroid hormones thyroxine and triiodotyronine contain iodine. In areas where there is little iodine in the diet—typically remote inland areas where no marine foods are eaten—iodine deficiency gives rise to goiter (so-called endemic goitre), as well as cretinism, which results in developmental delays and other health problems

In some such areas, this is now combatted by the addition of small amounts of iodine to table salt in form of sodium iodide, potassium iodide, potassium iodate—this product is known as iodized salt. Iodine compounds have also been added to other foodstuffs, such as flour, in areas of deficiency.

Pathophysiology

Goitre

Low amounts of thyroid hormones in the blood, due to lack of iodine to make them, give rise to high levels of the pituitary hormone TSH, which in turn stimulate abnormal growth of the thyroid gland, sometimes causing goitres.

Iodized salt and other sources of iodine in the diet has eliminated this condition in many affluent countries, however there are a number of European countries, Australia, and New Zealand where iodine deficiency is a significant public health problem (Andersson M, Takkouche B, Egli I, Allen HE, de Benoist B. Current global iodine status and progress over the last decade towards the elimination of iodine deficiency. Bull World Health Organ 2005;83:518-25). However, it is still common in poorer nations. Also, treatment for conditions such as hypertension proscribe the excessive intake of salt and prescribe the use of a salt substitute.

References

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Causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Causes

References

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Differentiating Iodine deficiency from other Diseases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Differential Diagnosis

References

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Epidemiology and Demographics

Template:Iodine deficieny Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Iodine is an essential trace element; the thyroid hormones thyroxine and triiodotyronine contain iodine. In areas where there is little iodine in the diet—typically remote inland areas where no marine foods are eaten—iodine deficiency gives rise to goiter (so-called endemic goitre), as well as cretinism, which results in developmental delays and other health problems In some such areas, this is now combatted by the addition of small amounts of iodine to table salt in form of sodium iodide, potassium iodide, potassium iodate—this product is known as iodized salt. Iodine compounds have also been added to other foodstuffs, such as flour, in areas of deficiency.

Epidemiology and Demographics

Certain areas of the world, due to natural deficiency and governmental inaction, are severely affected by iodine deficiency, which effects approximately two billion people worldwide. It is particularly common in the Netherlands, Western Pacific, South-East Asia and Africa. India is the most outstanding, with 500 million suffering from deficiency, 54 million from goitre, and two million from cretinism. Among other nations affected by iodine deficiency, China and Kazakhstan have begun taking action, while Russia has not. Successful campaigns for the adoption of the use of iodized salt require education and regulation of salt producers and sellers and a communication campaign directed at the public, the salt trade, politicians and policy makers. The cost of adding iodine to salt is negligible. [1]

References

  1. “In Raising the World’s I.Q., the Secret’s in the Salt”, article by Donald G. McNeil, Jr., December 16, 2006, New York Times

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Risk Factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Risk Factors

References

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Screening

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Screening

References

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Natural History, Complications and Prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Natural History

Complications

Prognosis

References

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Diagnosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case Studies

Case #1

References

References

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