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JAM2
Introduction
Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.[1][2][3] JAM2 has also been designated as CD322 (cluster of differentiation 322).
Function
Function
Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.[3]
It is purported to promote lymphocyte transendothelial migration.[4] It might also be involved with endothelial cell polarity, by associating to cell polarity protein PAR-3, together with JAM3.[5]
Interactions
Interactions
JAM2 has been shown to interact with PARD3.[5]
It also interacts with the integrin dimer VLA-4 (also called Ξ±4Ξ²1).[6]
References
References
- β Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD (Aug 2000). “Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells”. J Biol Chem. 275 (25): 19139β45. doi:10.1074/jbc.M003189200. PMIDΒ 10779521.
- β Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA (Nov 2000). “A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions”. J Biol Chem. 275 (44): 34750β6. doi:10.1074/jbc.M002718200. PMIDΒ 10945976.
- β 3.0 3.1 “Entrez Gene: JAM2 junctional adhesion molecule 2”.
- β Johnson-LΓ©ger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (October 2002). “Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration”. Blood. 100 (7): 2479β86. doi:10.1182/blood-2001-11-0098. PMIDΒ 12239159.
- β 5.0 5.1 Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003). “The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity”. J. Cell Sci. 116 (Pt 19): 3879β91. doi:10.1242/jcs.00704. PMIDΒ 12953056.
- β Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA (August 2002). “JAM2 interacts with alpha4beta1. Facilitation by JAM3”. J. Biol. Chem. 277 (31): 27589β92. doi:10.1074/jbc.C200331200. PMIDΒ 12070135.
Further reading
Further reading
- Muller WA (2003). “Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response”. Trends Immunol. 24 (6): 327β34. doi:10.1016/S1471-4906(03)00117-0. PMIDΒ 12810109.
- Bazzoni G (2004). “The JAM family of junctional adhesion molecules”. Curr. Opin. Cell Biol. 15 (5): 525β30. doi:10.1016/S0955-0674(03)00104-2. PMIDΒ 14519386.
- Hattori M, Fujiyama A, Taylor TD, et al. (2000). “The DNA sequence of human chromosome 21”. Nature. 405 (6784): 311β9. doi:10.1038/35012518. PMIDΒ 10830953.
- Hartley JL, Temple GF, Brasch MA (2001). “DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788β95. doi:10.1101/gr.143000. PMCΒ 310948. PMIDΒ 11076863.
- Arrate MP, Rodriguez JM, Tran TM, et al. (2002). “Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor”. J. Biol. Chem. 276 (49): 45826β32. doi:10.1074/jbc.M105972200. PMIDΒ 11590146.
- Liang TW, Chiu HH, Gurney A, et al. (2002). “Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3”. J. Immunol. 168 (4): 1618β26. doi:10.4049/jimmunol.168.4.1618. PMIDΒ 11823489.
- Gardiner K, Slavov D, Bechtel L, Davisson M (2002). “Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis”. Genomics. 79 (6): 833β43. doi:10.1006/geno.2002.6782. PMIDΒ 12036298.
- Cunningham SA, Rodriguez JM, Arrate MP, et al. (2002). “JAM2 interacts with alpha4beta1. Facilitation by JAM3”. J. Biol. Chem. 277 (31): 27589β92. doi:10.1074/jbc.C200331200. PMIDΒ 12070135.
- Aurrand-Lions M, Johnson-Leger C, Lamagna C, et al. (2004). “Junctional adhesion molecules and interendothelial junctions”. Cells Tissues Organs (Print). 172 (3): 152β60. doi:10.1159/000066967. PMIDΒ 12476045.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899β903. doi:10.1073/pnas.242603899. PMCΒ 139241. PMIDΒ 12477932.
- Ebnet K, Aurrand-Lions M, Kuhn A, et al. (2004). “The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity”. J. Cell Sci. 116 (Pt 19): 3879β91. doi:10.1242/jcs.00704. PMIDΒ 12953056.
- Clark HF, Gurney AL, Abaya E, et al. (2003). “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment”. Genome Res. 13 (10): 2265β70. doi:10.1101/gr.1293003. PMCΒ 403697. PMIDΒ 12975309.
- Zhang Z, Henzel WJ (2005). “Signal peptide prediction based on analysis of experimentally verified cleavage sites”. Protein Sci. 13 (10): 2819β24. doi:10.1110/ps.04682504. PMCΒ 2286551. PMIDΒ 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121β7. doi:10.1101/gr.2596504. PMCΒ 528928. PMIDΒ 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). “From ORFeome to biology: a functional genomics pipeline”. Genome Res. 14 (10B): 2136β44. doi:10.1101/gr.2576704. PMCΒ 528930. PMIDΒ 15489336.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry”. J. Proteome Res. 4 (6): 2070β80. doi:10.1021/pr0502065. PMCΒ 1850943. PMIDΒ 16335952.
External links
External links
- JAM2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.