Latrophilin

Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind the spider venom alpha-latrotoxin.^[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.^[2]

The precise functions of latrophilins remain unknown.^[2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.^[3]

Human proteins containing this domain

Latrophilin 1 (LPHN1)
Latrophilin 2 (LPHN2)
Latrophilin 3 (LPHN3)

References

↑ Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). “Interaction of G-protein-coupled receptors with synaptic scaffolding proteins”. Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID 12196116.
↑ ^2.0 ^2.1 Silva, JP; Ushkaryov, YA (2010). “The latrophilins, “split-personality” receptors”. Advances in Experimental Medicine and Biology. 706: 59–75. doi:10.1007/978-1-4419-7913-1_5. PMC 3145135. PMID 21618826.
↑ Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). “Latrophilins updated”. Biomolecular Concepts. 5 (6). doi:10.1515/bmc-2014-0032.

[pmid12196116-1] Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). “Interaction of G-protein-coupled receptors with synaptic scaffolding proteins”. Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID 12196116.

[JPS-2] 2.0 ^2.1 Silva, JP; Ushkaryov, YA (2010). “The latrophilins, “split-personality” receptors”. Advances in Experimental Medicine and Biology. 706: 59–75. doi:10.1007/978-1-4419-7913-1_5. PMC 3145135. PMID 21618826.

[3] Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). “Latrophilins updated”. Biomolecular Concepts. 5 (6). doi:10.1515/bmc-2014-0032.

[1]

[2]

[3]

Latrophilin

Human proteins containing this domain

See also

References

Looking for the patient version?