
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
List of molecular biology topics
Introduction
Overview
Overview
This is a list of topics in molecular biology. See also list of biochemistry topics.
A
A
acrylamide gels – adenine – adenosine deaminase deficiency – adenovirus – agarose gel electrophoresis – agarose gel – Alagille syndrome – alkaline lysis – allele – amino acids – amino terminus – amp resistance – amplification – amplicon – anchor sequence – animal model – anneal – anti-sense strand – antibiotic resistance – antibody – antisense – antisense strand – AP-1 site – apoptosis – assembled epitope – ataxia-telangiectasia – ATG or AUG – autoimmune lymphoproliferative syndrome – autoradiography – autosomal dominant – autosome – avidin –
B
B
BAC – back mutation – bacteria – bacterial artificial chromosome – bacteriophage – bacteriophage lambda – band shift assay – base – base pair – binding site – biotin – birth defect – blotting – blunt end – bone marrow transplantation – box – BP – BRCA1 – BRCA2 –
C
C
C terminus – cancer – candidate gene – Canonical sequence – cap – cap site – carboxyl terminus – carcinoma – carrier – CAT assay – CCAAT box – cDNA – cDNA clone – cDNA library – cell – centimorgan – centromere – chain terminator – chaperone protein – chromosome – chromosome walking – CIS – cistron – clone (genetics) – clone (noun) – clone (verb) – cloning – coding sequence – coding strand – codon – codon usage bias – competent – complementary – conformational epitope – congenital – consensus sequence – conservative substitution – conserved – contig – cosmid – craniosynostosis – cystic fibrosis – cytogenetic map – cytosine – CpG
D
D
database search – degeneracy – deletion – denaturation – denaturing gel – deoxyribonuclease (DNase) – deoxyribonucleic acid – deoxyribonucleotide – diabetes mellitus – dideoxy sequencing – dideoxyribonucleotide – diploid – direct repeat – DNA ligase –DNA Bank – DNA polymerase – DNA replication – DNA sequencing – DNase – dominant – dot blot – double helix – downstream (molecular biology) – ds – duplex –
E
E
E. coli – electrophoresis – electroporation – Ellis-van Creveld syndrome – end labeling – endonuclease – enhancer – enzyme – epitope – ERE – ethidium bromide – evolutionary clock – evolutionary footprinting – exon – exonuclease – expression – expression clone – expression vector –
F
F
familial Mediterranean fever – fibroblasts – fluorescence in situ hybridization – footprinting – Fragile X syndrome – frameshift mutation – fusion protein –
G
G
gel electrophoresis – gel shift – gel shift assay – gene – gene amplification – gene conversion – gene expression – gene mapping – gene pool – gene therapy – gene transfer – genetic code – genetic counseling – genetic map – genetic marker – genetic screening – genome – genomic blot – genomic clone – genomic library – genotype – germ line – glycoprotein – glycosylation – Golgi apparatus – GRE – guanine –
H
H
hairpin – haploid – haploinsufficiency – helix-loop-helix – hematopoietic stem cell – hemophilia – heteroduplex DNA – heterozygous – highly conserved sequence – Hirschsprung’s disease – histone – hnRNA – holoprosencephaly – homologous recombination – homology – homozygous – host strain (bacterial) – human artificial chromosome – Human Genome Project – human immunodeficiency virus – Huntington’s disease – hybridization – hybridoma – hydrophilicity plot –
I
I
immunoblot – immunoprecipitation – immunotherapy – in situ hybridization – in vitro translation – inducer – inherited – initiation codon – insert – insertion – insertion sequence – intellectual property rights – intergenic – intron – inverted repeat –
K
K
karyotype – kilobase – kinase – Klenow fragment – Knock-down – knock-out – knock-out experiment – knockout – Kozak sequence
L
L
lambda – leucine zipper – leukemia – library – ligase – linear epitope – linkage – linker – lipofectin – locus – LOD score – lymphocyte –
M
M
M13 phage – malformation – mapping – marker – melanoma – melting – Johann Mendel – Mendelian inheritance – message – messenger RNA – metaphase – microarray technology – microsatellite – missense mutation – mitochondrial DNA – mobility shift – molecular weight size marker – monoclonal antibody – monosomy – mouse model – mRNA – multicistronic message – multicopy plasmid – multiple cloning site – multiple endocrine neoplasia, type 1 – mutation –
N
N
N terminus – native gel – nested PCR – neurofibromatosis – nick (DNA) – nick translation – Niemann-Pick disease, type C – non-coding DNA – non-coding strand – non-directiveness – nonconservative substitution – nonsense codon – nonsense mutation – nontranslated RNA – Northern blot – NT – nuclear run-on – nuclease – nuclease protection assay – nucleoside – nucleotide – nucleus –
O
O
oligo – oligodeoxyribonucleotide – oligonucleotide – oncogene – oncovirus – open reading frame – operator – operon – origin of replication – overhang –
P
P
p53 – package – palindromic sequence – Parkinson’s disease – pBR322 – PCR – pedigree – peptide – peptide bond – phage – phagemid – phenotype – phosphatase, alkaline – phosphodiester bond – phosphorylation – physical map – plasmid – point mutation – poly-A track – polyA tail – polyacrylamide gel – polyclonal antibodies – polydactyly – polymerase – polymerase chain reaction – polymorphism – polynucleotide kinase – polypeptide – positional cloning – post-transcriptional regulation – post-translational modification – post-translational processing – post-translational regulation – PRE – Precursor mRNA – primary immunodeficiency – primary transcript – primer – primer extension – probe – processing – processivity – promoter – pronucleus – prostate cancer – protease – protein – proto-oncogene – pseudogene – pseudoknot – pseudorevertant – pulse sequence database – pulsed field gel electrophoresis – purine – pyrimidine
R
R
random primed synthesis – reading frame – recessive – recognition sequence – recombinant DNA – recombination – recombination-repair – relaxed DNA – repetitive DNA – replica plating – reporter gene – repression – repressor – residue – response element – restriction – restriction endonuclease – restriction enzyme – restriction fragment – restriction fragment length polymorphism (RFLP) – restriction fragments – restriction map – restriction site – reticulocyte lysate – retrovirus – reverse transcriptase – reverse transcription – revertant – ribonuclease – ribonuclease – ribonucleic acid – riboprobe – ribosomal binding sequence – ribosome – ribozyme – risk communication – RNA polymerase – RNA splicing – RNAi – RNase – RNase protection assay – rRNA – RT-PCR – run-off – Run-on – runoff transcript
S
S
S1 end mapping – S1 nuclease – screening – SDS-PAGE – secondary structure – selection – sense strand – sequence – sequence motif – sequence polymorphism – sequence-tagged site – sequential epitope – severe combined immunodeficiency – sex chromosome – sex-linked – Shine-Dalgarno sequence – shotgun cloning – shotgun cloning or sequencing – shotgun sequencing – shuttle vector – sickle-cell disease – side chain – sigma factor – signal peptidase – signal sequence – silent mutation – single nucleotide polymorphism – siRNA – site-directed mutagenesis – site-specific recombination – slot blot – SNP – snRNA – snRNP – solution hybridization – somatic cells – Southern blot – southwestern blot – SP6 RNA polymerase – spectral karyotype – splicing – Simple Sequence Repeats (SSR) – stable transfection – start codon – stem-loop – sticky end – stop codon – streptavidin – stringency – structural motif – sub-cloning – substitution – suicide gene – supercoil – syndrome –
T
T
T7 RNA polymerase – taq polymerase – TATA box – technology transfer – template – termination codon – terminator – tertiary structure – tet resistance – thymine – tissue-specific expression – tm – trans – transcript – transcription – transcription factor – transcription/translation reaction – transcriptional start site – transfection – Transformation (genetics) – transformation (with respect to bacteria) – transfection (with respect to cultured cells) – transgene – transgenic – transgenic mouse – transient transfection – transition – translation – translocation – transposition – transposon – transversion – triplet – trisomy – tRNA – tumor suppressor – tumor suppressor gene –
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
