
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Mirizzi's syndrome pathophysiology
Introduction
Overview
Overview
Pathophysiology
Pathophysiology
- Mirizzi’s syndrome is caused by gallstone impaction in the cystic duct or neck of gallbladder resulting in chronic inflammation that leads to the compression, necrosis and fibrosis of common bile duct.
- This can result in fistula formation into the adjacent structures like common hepatic duct or common bile duct.
- The obstruction of bile duct either by direct compression from gallstone or scar formation results in obstructive jaundice.
- It can be divided into the following types: [1]
- Type I lesions involve external compression of the common bile duct without any fistula formation.
- Type II lesions involve cholecystobiliary fistula with erosion of less than one‐third of the circumference of the bile duct.
- Type III lesions are fistula that involve up to two‐thirds of the duct circumference.
- Type IV lesions are complete destruction of the bile duct. [2]
References
References
- ↑ 1.0 1.1 Beltrán MA (September 2012). “Mirizzi syndrome: history, current knowledge and proposal of a simplified classification”. World J. Gastroenterol. 18 (34): 4639–50. doi:10.3748/wjg.v18.i34.4639. PMC 3442202. PMID 23002333.
- ↑ Csendes A, Díaz JC, Burdiles P, Maluenda F, Nava O (November 1989). “Mirizzi syndrome and cholecystobiliary fistula: a unifying classification”. Br J Surg. 76 (11): 1139–43. doi:10.1002/bjs.1800761110. PMID 2597969.
- ↑ Chen H, Siwo EA, Khu M, Tian Y (January 2018). “Current trends in the management of Mirizzi Syndrome: A review of literature”. Medicine (Baltimore). 97 (4): e9691. doi:10.1097/MD.0000000000009691. PMC 5794376. PMID 29369192.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
