Morton’s neuroma is associated with symptomatic collapse of the transverse arch by perineural fibrosis around a plantar digital nerve of the foot due to chronic traction and increased pressure/compression on the interdigital nerve. It is located at the third intermetatarsal space most commonly (between third and fourth metatarsals), and sometimes second or fourth interspaces or bifurcation of the fourth plantar digital nerve. Gross pathological features of morton’s neuroma include adherent fibrofatty tissue, small, firm, oval, yellowish–white, slowly growing, palpable nodule on skin (no discoloration of skin on the top of nodule) and </=2cm in size. Histopathological analysis is characterized by extensive fibrosis around and within the nerve, digital artery, thrombosis, epineural and endoneural arterial thickening/vascular hyalinization, and degenerated/demyelinated axons. Possible tissue pathologies associated with interdigital pain of morton’s neuroma include perineural fibrosis, endoneural edema, neurofibromata, angioneurofibromata, local demyelination, and local vascular degeneration.

• Morton’s neuroma is associated with symptomatic collapse of the transverse arch by perineural fibrosis around a plantar digital nerve of the foot due to chronic traction and increased pressure/compression on the interdigital nerve^{[1][2][3][4][5][6]}

• Morton’s neuroma is characterized by being located at the:
  • Third intermetatarsal space most commonly (between third and fourth metatarsals)^[7]
  • Second or fourth interspaces
  • Bifurcation of the fourth plantar digital nerve

• On gross pathology, characteristic findings of morton’s neuroma, include:^[8][9]
  • Adherent fibrofatty tissue
  • Small, firm, oval, yellowish–white, slowly growing, palpable nodule on skin (no discoloration of skin on the top of nodule)
  • </=2cm in size

• On microscopic histopathological analysis, characteristic findings of morton’s neuroma include:^{[10][8][9][2]}
  • Extensive fibrosis around and within the nerve
  • Digital artery
  • Thrombosis
  • Epineural and endoneural arterial thickening/vascular hyalinization
  • Degenerated/demyelinated axons

Possible tissue pathologies associated with interdigital pain of morton’s neuroma include:^[11]

• Perineural fibrosis
• Endoneural edema
• Neurofibromata
• Angioneurofibromata
• Local demyelination
• Local vascular degeneration