Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Neurofibroma historical perspective
Introduction
Overview
Overview
NF1-like cutaneous tumor syndromes appeared in the literature in 1880s, when Friedrich von Recklinghausen published seminal observations detailing cutaneous tumors comprised of both neuronal and fibroblastic tissue finally termed as neurofibromas. In 2006, Yang et al demonstrated a critical neurofibroma microenvironment interaction that includes SCF–stimulated Nf1+/− mast cells potentiating Nf1+/− fibroblast functions.
Historical Perspective
Historical Perspective
- In 18th century, NF1-like cutaneous tumor syndromes appeared in the literature.[1]
- In 1880s, Friedrich von Recklinghausen published seminal observations detailing cutaneous tumors comprised of both neuronal and fibroblastic tissue finally termed as neurofibromas.
- In 2006, Yang et al demonstrated a critical neurofibroma microenvironment interaction that includes SCF–stimulated Nf1+/− mast cells potentiating Nf1+/− fibroblast functions.[2]
References
References
- ↑ Morse RP (1999). “Neurofibromatosis type 1”. Arch Neurol. 56 (3): 364–5. PMID 10190829.
- ↑ Staser, Karl; Yang, Feng-Chun; Clapp, D. Wade (2010). “Mast cells and the neurofibroma microenvironment”. Blood. 116 (2): 157–164. doi:10.1182/blood-2009-09-242875. ISSN 0006-4971.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]