
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Non-alcoholic fatty liver disease surgery
Introduction
Overview
Overview
Surgery is not the first-line treatment option for patients with non- Alcoholic fatty liver disease (NAFLD). However, gastric bypass surgery is recommended in patients with non-alcoholic fatty liver disease whose BMI is greater than 35 particularly in those without improvement in imaging-detected hepatic steatosis or fibrosis after behavioral modification or medication therapy.
Surgery
Surgery
Indications
- Patients with NAFLD and BMI greater than 35 who psychologically stable[1]
- In patients who failed medical therapy.
Surgical options
- The most common procedures are adjustable gastric banding and the Roux-en-Y bypass.[2]
- A Y-shaped section of the i bum is attached to the pouch so that food bypasses the duodenum and proximal section of the jejunum.
- A laparoscopic sleeve gastrectomy may be a secure and powerful treatment of weight problems in adult patients. Significant and sustained weight reduction results in the improvement NAFLD.[3][4]
- The size of the stomach is reduced either by stapling or banding, creating a small pouch, assisting with weight loss by inducing
- Earlier satiety
- Reducing caloric intake
- Decreasing absorptive capacity
- The feasibility of liver transplantation depends on the stage of NAFLD at diagnosis.NAFLD is emerging as the second most common cause for liver transplant.[5][6]
- Indication 1 End stage liver-diseaseÂ
- Indication 2 Hepatocellular carcinoma (HCC) are the two most important indications for the liver transplant.
- Outcome : After liver transplanation patients with or without NASH may survive 1,3 and 5 years and are increasinly at risk for cardio vascular risks.[7]
Complications
- Early complications include:
- Late complications include
References
References
- ↑ Tilg H, Petta S, Stefan N, Targher G (January 2026). “Metabolic Dysfunction-Associated Steatotic Liver Disease in Adults: A Review”. JAMA. 335 (2): 163–174. doi:10.1001/jama.2025.19615. PMID 41212550 Check
|pmid=value (help). - ↑ Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J (2017). “Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies”. J Clin Transl Hepatol. 5 (1): 67–75. doi:10.14218/JCTH.2016.00061. PMC 5411359. PMID 28507929.
- ↑ Boscolo M, Féry F, Cnop M (2017). “Beneficial Outcomes of Sleeve Gastrectomy in a Morbidly Obese Patient With Bardet-Biedl Syndrome”. J Endocr Soc. 1 (4): 317–322. doi:10.1210/js.2017-00071. PMID 29264490.
- ↑ Colquitt JL, Pickett K, Loveman E, Frampton GK (2014). “Surgery for weight loss in adults”. Cochrane Database Syst Rev (8): CD003641. doi:10.1002/14651858.CD003641.pub4. PMID 25105982.
- ↑ Germani G, Becchetti C (2017). “Liver transplantation for non-alcoholic fatty liver disease”. Minerva Gastroenterol Dietol. doi:10.23736/S1121-421X.17.02467-9. PMID 29249127.
- ↑ Cholankeril G, Wong RJ, Hu M, Perumpail RB, Yoo ER, Puri P, Younossi ZM, Harrison SA, Ahmed A (2017). “Liver Transplantation for Nonalcoholic Steatohepatitis in the US: Temporal Trends and Outcomes”. Dig. Dis. Sci. 62 (10): 2915–2922. doi:10.1007/s10620-017-4684-x. PMID 28744836.
- ↑ Wang X, Li J, Riaz DR, Shi G, Liu C, Dai Y (2014). “Outcomes of liver transplantation for nonalcoholic steatohepatitis: a systematic review and meta-analysis”. Clin. Gastroenterol. Hepatol. 12 (3): 394–402.e1. doi:10.1016/j.cgh.2013.09.023. PMID 24076414.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]Parth Vikram Singh, MBBS[3]
