Omphalitis is most commonly caused by bacteria. The most common bacteria are Staphylococcus aureus, Streptococcus, Escherichia Coli and Klebsiella pneumoniae. The infection is typically caused by a mix of these organisms and is, thus, a mixed Gram-positive and Gram-negative infection. Anaerobic bacteria can also be involved. A common cause of omphalitis is improper cord care.

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

• Sepsis

• Improper cord care