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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Osteosarcoma classification

Introduction

Overview

Overview

Osteosarcoma (OS) is a rare bone cancer which affects both adolescents and young adults. Osteosarcoma was classified as primary and secondary. Later the the World Health Organization sub-typed as intramedullary/central and surface osteosarcoma with a number of sub-types under each group.

Classification

Classification

Classification of osteosarcoma
  • Unusual forms of osteosarcoma given below are viewed as subtypes of conventional osteosarcoma because their biological behavior is similar.
Osteosarcoma (Primary) subtypes within central and surface tumours
subtypes Osteosarcoma
CENTRAL (MEDULLARY) A. Conventional high-grade central osteosarcoma (80%)

B. Telangiectatic osteosarcoma (4%)

C. Intraosseous well-differentiated (low-grade) osteosarcoma (1-2%)

D. Small cell osteosarcoma (1-2%)

SURFACE (PERIPHERAL) a. Parosteal (juxtacortical) well-differentiated (low-grade) osteosarcoma(4-6%)

b. Periosteal osteosarcoma– low- to intermediate-grade osteosarcoma(<4%)

c. High-grade surface osteosarcoma(1%)

    References

    References

    1. ↑ 1.0 1.1 Duong LM, Richardson LC (2013). “Descriptive epidemiology of malignant primary osteosarcoma using population-based registries, United States, 1999-2008”. J Registry Manag. 40 (2): 59–64. PMC 4476493. PMID 24002129.
    2. ↑ Bielack SS, Hecker-Nolting S, Blattmann C, Kager L (2016). “Advances in the management of osteosarcoma”. F1000Res. 5: 2767. doi:10.12688/f1000research.9465.1. PMC 5130082. PMID 27990273.
    3. ↑ Kundu ZS (May 2014). “Classification, imaging, biopsy and staging of osteosarcoma”. Indian J Orthop. 48 (3): 238–46. doi:10.4103/0019-5413.132491. PMC 4052020. PMID 24932027.
    4. ↑ 4.0 4.1 Misaghi A, Goldin A, Awad M, Kulidjian AA (2018). “Osteosarcoma: a comprehensive review”. SICOT J. 4: 12. doi:10.1051/sicotj/2017028. PMC 5890448. PMID 29629690.
    5. ↑ Ozaki T, Flege S, Liljenqvist U, Hillmann A, Delling G, Salzer-Kuntschik M, Jürgens H, Kotz R, Winkelmann W, Bielack SS (February 2002). “Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group”. Cancer. 94 (4): 1069–77. PMID 11920477.
    6. ↑ Hamre MR, Severson RK, Chuba P, Lucas DR, Thomas RL, Mott MP (December 2002). “Osteosarcoma as a second malignant neoplasm”. Radiother Oncol. 65 (3): 153–7. PMID 12464443.
    7. ↑ Barker JP, Monument MJ, Jones KB, Putnam AR, Randall RL (May 2015). “Secondary osteosarcoma: is there a predilection for the chondroblastic subtype?”. Orthopedics. 38 (5): e359–66. doi:10.3928/01477447-20150504-51. PMID 25970361.

    Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].