Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
PVT1
Introduction
Pvt1 oncogene (non-protein coding), also known as PVT1, is a long non-coding RNA gene.[1] In mice, this gene was identified as a breakpoint site in chromosome 6;15 translocations. These translocations are associated with murine plasmacytomas.[2] The equivalent translocation in humans is t(2;8), which is associated with a rare variant of Burkitt’s lymphoma.[3] In rats, this breakpoint was shown to be a common site of proviral integration in retrovirally induced T lymphomas.[4] Transcription of PVT1 is regulated by Myc.[5]
References
References
- ↑ “Entrez Gene: PVT1 Pvt1 oncogene homolog, MYC activator (mouse)”.
- ↑ Cory S, Graham M, Webb E, Corcoran L, Adams JM (1985). “Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene”. EMBO J. 4 (3): 675–81. PMC 554241. PMID 3924592.
- ↑ Graham M, Adams JM (1986). “Chromosome 8 breakpoint far 3′ of the c-myc oncogene in a Burkitt’s lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus”. EMBO J. 5 (11): 2845–51. PMC 1167233. PMID 3024964.
- ↑ Villeneuve L, Rassart E, Jolicoeur P, Graham M, Adams JM (1986). “Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas”. Mol Cell Biol. 6 (5): 1834–7. PMC 367714. PMID 3785181.
- ↑ Carramusa L, Contino F, Ferro A, Minafra L, Perconti G, Giallongo A, et al. (2007). “The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells”. J Cell Physiol. 213 (2): 511–8. doi:10.1002/jcp.21133. PMID 17503467.
Further reading
Further reading
- Guan Y, Kuo WL, Stilwell JL, et al. (2007). “Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer”. Clin. Cancer Res. 13 (19): 5745–55. doi:10.1158/1078-0432.CCR-06-2882. PMID 17908964.
- Millis MP, Bowen D, Kingsley C, et al. (2007). “Variants in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes”. Diabetes. 56 (12): 3027–32. doi:10.2337/db07-0675. PMID 17881614.
- Carramusa L, Contino F, Ferro A, et al. (2008). “The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells”. J. Cell. Physiol. 213 (2): 511–8. doi:10.1002/jcp.21133. PMID 17503467.
- Hanson RL, Craig DW, Millis MP, et al. (2007). “Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study”. Diabetes. 56 (4): 975–83. doi:10.2337/db06-1072. PMID 17395743.
- Oh JH, Yang JO, Hahn Y, et al. (2006). “Transcriptome analysis of human gastric cancer”. Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Graham M, Adams JM (1987). “Chromosome 8 breakpoint far 3′ of the c-myc oncogene in a Burkitt’s lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus”. EMBO J. 5 (11): 2845–51. PMC 1167233. PMID 3024964.
- Shtivelman E, Bishop JM (1989). “The PVT gene frequently amplifies with MYC in tumor cells”. Mol. Cell. Biol. 9 (3): 1148–54. PMC 362705. PMID 2725491.
- Shtivelman E, Henglein B, Groitl P, et al. (1989). “Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma”. Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3257–60. doi:10.1073/pnas.86.9.3257. PMC 287109. PMID 2470097.
- Shtivelman E, Bishop JM (1990). “Effects of translocations on transcription from PVT”. Mol. Cell. Biol. 10 (4): 1835–9. PMC 362296. PMID 2181290.