The incidence of pancreatic fistula following pancreatic resection surgery varies from 5% to 26%. The overall mortality risk due to pancreatic fistula is 1%, however patients with grade C pancreatic fistula carries a mortality risk of 25%.

• Pancreatic fistula is a known complication following surgical resection of the pancreas.
• The incidence rate varies from as low as 5% in high volume centers to as high as 26%.^[1]
• The incidence of pancreatic fistula varies depending on the type of pancreatic resection as it can be as low as 3% following a pancreatic head resection to as high as 30% after distal pancreatectomy.^[2][3]
• Acute fluid collection is recorded in up to 40% patients with acute pancreatitis, out of which some cases develops true pancreatic fistula depending upon the severity of the insult.^[4]

• Pancreatic fistula can lead to certain severe complications if not addressed on time, as it carries a mortality risk of 25% in patients with grade C pancreatic fistula.
• Post-operative pancreatic fistulae can affect 13% to 41% of patients after pancreatic resection, making it a known source of morbidity and mortality.