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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Peripheral arterial disease causes

Introduction

Overview

Overview

Peripheral arterial disease (PAD) is most commonly a manifestation of atherosclerosis resulting from vascular inflammation. Other uncommon causes should be suspected when the PAD occurs at a young age and in the context of a positive history. Uncommon causes include degenerative diseases (Marfan’s syndrome and Ehlers-Danlos syndrome), dysplastic disorders (fibromuscular dysplasia), inflammatory diseases (arteritis) and hypercoagulable states.

Causes

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular Arterial dissection, arteriomegaly, arteritis, atheroembolism, atherosclerosis, Buergers disease, cystic adventitial disease, Erdheim cystic medial necrosis, fibromuscular dysplasia, hypertension, Leriche’s syndrome, multifocal fibrosclerosis, Sneddon syndrome, Takayasu’s arteritis, temporal arteritis, thromboangiitis obliterans, thromboembolism, thrombosed aneurysm, vasculitis
Chemical / poisoning Ergot use
Dermatologic Sneddon syndrome, vasculitis
Drug Side Effect Ergot use
Ear Nose Throat No underlying causes
Endocrine Diabetes
Environmental Smoking
Gastroenterologic No underlying causes
Genetic Deafness peripheral neuropathy and arterial disease, Ehlers-Danlos syndrome, heterozygous familial hypercholesterolemia, Marfan’s syndrome, neurofibromatosis, pseudoxanthoma elasticum
Hematologic Hypercoagulable state, thrombophilia, thrombosis
Iatrogenic Radiation arteritis, radiation fibrosis, surgery, thrombosis
Infectious Disease No underlying causes
Musculoskeletal / Ortho No underlying causes
Neurologic Neurofibromatosis, Sneddon syndrome
Nutritional / Metabolic Hyperlipidemia, homocysteinemia, lipoproteinemia
Obstetric/Gynecologic No underlying causes
Oncologic Cancer, tumor
Opthalmologic Sneddon syndrome
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Buergers disease, retroperitoneal fibrosis, Sneddon syndrome, thromboangiitis obliterans, vasculitis
Sexual No underlying causes
Trauma Iliac endofibrosis (athletic injury), limb trauma, popliteal artery entrapment syndrome
Urologic Retroperitoneal fibrosis
Dental No underlying causes
Miscellaneous Obesity

Causes in Alphabetical Order

References

References

  1. ↑ Okello S, Millard A, Owori R, Asiimwe SB, Siedner MJ, Rwebembera J; et al. (2014). “Prevalence of lower extremity peripheral artery disease among adult diabetes patients in southwestern Uganda”. BMC Cardiovasc Disord. 14: 75. doi:10.1186/1471-2261-14-75. PMC 4057935. PMID 24913468.


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Cafer Zorkun, M.D., Ph.D. [2]; Rim Halaby