Common physical examination findings of Peutz-Jeghers syndrome include mucocutaneous hyperpigmentation, abdominal tenderness due to intussusception, bowel obstruction, and pallor due to anemia.

The physical exam findings are as follows:^[1][2]

• Cachexia may be suggestive of cancer.

• Fever

• Tachypnea

• Patches of hyperpigmentation on the hands and feet
• Jaundice may be suggestive of pancreatic cancer

• Icteric sclera

• Oral mucosa

• Mucocutaneous pigmentation causing patches of hyperpigmentation in the oral mucosa (gingiva, hard palate, buccal mucosa, and labial mucosa)

• Lymphadenopathy

• If lung cancer develops, the patient may present with the following:

• Wheezing
• Consolidation with reduced breath sounds on auscultation
• Rales
• Egophony
• Chest movement may be asymmetric

• Abdominal distention
• Abdominal tenderness
• Rebound tenderness
• An acute abdomen may be suggestive of intussusception
• An abdominal mass may be suggestive of hepatic or pancreatic cancer
• Guarding
• Hepatomegaly may be suggestive of hepatic cancer

• Patches of hyperpigmentation on the hands and feet
• Clubbing may be suggestive of lung cancer
• Cyanosis may be suggestive of lung cancer